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Project ColMod
Ready for outlicensing |
In this project, AnaMar is developing a novel wound healing agent. The wound healing process can be divided into three phases: the inflammatory, the proliferative, and the remodelling phase. These phases require fine-tuned interplay between various cell types and tissue components, allowing the repair process to proceed to completion. The extracellular matrix (ECM) is a major structural component of the skin and serves as a template for tissue regeneration during wound healing. Chronic wounds are characterized by metabolic disturbances and ECM deficiency. The deficient composition and organization of the ECM may lead to aberrant responses of endothelial cells, fibroblasts, and keratinocytes, resulting in non-healing. |
Therapeutic area: |
| Wound healing, topical treatment |
Stage of development: |
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Mechanism of action: |
| Our wound healing agent accelerates the formation of collagen fibrils and thereby promotes the restoration of a functional ECM. The newly established ECM supports angiogenesis and forms the substrate upon which fibroblasts and keratinocytes proliferate and migrate. It also regulates the activity of soluble mediators of wound healing, e.g. growth factors, cytokines, and proteases. |
Competitive advantages: |
- Novel mechanism of action
- Novel intellectual property
- Biocompatibility
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